Tetranectin, a trimeric plasminogen-binding C-type lectin

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The plasminogen binding site of the C-type lectin tetranectin is located in the carbohydrate recognition domain, and binding is sensitive to both calcium and lysine.

Tetranectin, a homotrimeric protein belonging to the family of C-type lectins and structurally highly related to corresponding regions of the mannose-binding proteins, is known specifically to bind the plasminogen kringle 4 protein domain, an interaction sensitive to lysine. Surface plasmon resonance and isothermal calorimetry binding analyses using single-residue and deletion mutant tetranecti...

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ژورنال

عنوان ژورنال: Protein Science

سال: 1997

ISSN: 0961-8368,1469-896X

DOI: 10.1002/pro.5560060715